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NeuroD Antibody

APR08711G Product Datasheet Protocol

货号	货期	规格 / 价格	询价
APR08711G		100 μl / ￥5450

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NeuroD Antibody

品牌	Leading Biology	货号	APR08711G
产品分类	Monoclonal Antibodies	研究领域
产品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NeuroD antibody.
分子量	40kDa
细胞定位	Antigen Cellular Localization: Cytoplasm. Nucleus {ECO:0000255\|PROSITE-ProRule:PRU00981, ECO:0000269\|PubMed:14752053}. Note=In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation (By similarity). Colocalizes with NR0B2 in the nucleus.
宿主	Mouse
种属反应性	Human, Mouse
克隆号	6E9G12
亚型	IgG1
通用名	BHLHA3, NEUROD
基因ID	4760
UniProt ID	Q13562
功能	Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).
形式	Liquid. In PBS containing 0.02% sodium azide.
储存条件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
应用	WB, E
稀释方法	E~~1/10000 WB~~1/500 - 1/2000
别名	Neurogenic differentiation factor 1, NeuroD, NeuroD1, Class A basic helix-loop-helix protein 3, bHLHa3, NEUROD1, BHLHA3, NEUROD
图像	Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng); Figure 1: Western blot analysis using Neurod mAb against human Neurod recombinant protein. (Expected MW is 33.2 kDa) Figure 2: Western blot analysis using Neurod mAb against HEK293 (1) and Neurod (AA: 26-91)-hIgGFc transfected HEK293 (2) cell lysate.
说明书	Product Datasheet Protocol
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