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SIRT4 Antibody

APR09960G Product Datasheet Protocol

货号	货期	规格 / 价格	询价
APR09960G		100 μl / ￥5450

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SIRT4 Antibody

品牌	Leading Biology	货号	APR09960G
产品分类	Monoclonal Antibodies	研究领域
产品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SIRT4 antibody.
分子量	35.2kDa
细胞定位	Antigen Cellular Localization: Mitochondrion matrix {ECO:0000255\|HAMAP- Rule:MF_03161, ECO:0000269\|PubMed:16079181, ECO:0000269\|PubMed:16959573, ECO:0000269\|PubMed:17715127}
宿主	Mouse
种属反应性	Human
克隆号	6G6D2
亚型	IgG1
通用名	SIR2L4
基因ID	23409
UniProt ID	Q9Y6E7
功能	Acts both as NAD-dependent protein ADP-ribosyl transferase and NAD-dependent protein deacetylase. Catalyzes the transfer of ADP-ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1: expressed in response to DNA damage and negatively regulates anaplerosis by inhibiting GLUD1, leading to block metabolism of glutamine into tricarboxylic acid cycle and promoting cell cycle arrest. In response to mTORC1 signal, SIRT4 expression is repressed, promoting anaplerosis and cell proliferation. Acts as a tumor suppressor. Also acts as a NAD-dependent protein deacetylase: mediates deacetylation of 'Lys- 471' of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. Down-regulates insulin secretion.
形式	Liquid. In PBS containing 0.02% sodium azide.
储存条件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
应用	WB, IHC, FC, ICC, E
稀释方法	E~~1/10000 WB~~1/500 - 1/2000 IF~~1/100 - 1/500 FC~~1/200 - 1/400
别名	NAD-dependent protein deacetylase sirtuin-4 {ECO:0000255\|HAMAP-Rule:MF_03161}, 3.5.1.- {ECO:0000255\|HAMAP-Rule:MF_03161}, NAD-dependent ADP-ribosyltransferase sirtuin-4 {ECO:0000255\|HAMAP-Rule:MF_03161}, 2.4.2.- {ECO:0000255\|HAMAP-Rule:MF_03161}, Regulatory protein SIR2 homolog 4 {ECO:0000255\|HAMAP-Rule:MF_03161}, SIR2-like protein 4 {ECO:0000255\|HAMAP-Rule:MF_03161}, SIRT4 {ECO:0000255\|HAMAP-Rule:MF_03161}, SIR2L4
图像	Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng); Figure 2:Western blot analysis using SIRT4 mAb against human SIRT4 (AA: 215-314) recombinant protein. (Expected MW is 37 kDa) Figure 3:Western blot analysis using SIRT4 mAb against HEK293 (1) and SIRT4 (AA: 215-314)-hIgGFc transfected HEK293 (2) cell lysate.
说明书	Product Datasheet Protocol
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