全部产品分类
品牌 |
Leading Biology | 货号 |
APR13044G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality RAB27A antibody.
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分子量 |
24.9kDa
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细胞定位 |
Antigen Cellular Localization:
Membrane; Lipid-anchor. Melanosome. Late endosome. Lysosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles
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宿主 |
Mouse
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种属反应性 |
Human
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克隆号 |
4D3F11
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亚型 |
IgG2b
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通用名 |
RAB27
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基因ID |
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UniProt ID |
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功能 |
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse.
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总结 |
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. ; ;
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形式 |
Liquid. In PBS containing 0.02% sodium azide.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
E~~1/10000
WB~~1/500 - 1/2000
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别名 |
Ras-related protein Rab-27A, Rab-27, GTP-binding protein Ram, RAB27A, RAB27
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图像 |
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说明书 |
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数量 |
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