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KLF1 Antibody

APR08103G Product Datasheet Protocol

货号	货期	规格 / 价格	询价
APR08103G		100 μl / ￥5450

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KLF1 Antibody

品牌	Leading Biology	货号	APR08103G
产品分类	Monoclonal Antibodies	研究领域
产品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality KLF1 antibody.
分子量	38.2kDa
细胞定位	Antigen Cellular Localization: Nucleus. Note=Colocalizes with SUMO1 in nuclear speckles.
宿主	Mouse
种属反应性	Human
克隆号	1B6A3
亚型	IgG1
通用名	EKLF
基因ID	10661
UniProt ID	Q13351
功能	Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation (By similarity).
总结	This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects.
形式	Liquid. In PBS containing 0.02% sodium azide.
储存条件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
应用	WB, IHC, FC, E
稀释方法	E~~1/10000 WB~~1/500 - 1/2000 FC~~1/200 - 1/400 IHC~~1/200 - 1/1000
别名	Krueppel-like factor 1, Erythroid krueppel-like transcription factor, EKLF, KLF1, EKLF
图像	Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng); Figure 1: Western blot analysis using KLF1 mAb against human KLF1 recombinant protein. (Expected MW is 42.6 kDa) Figure 2: Flow cytometric analysis of HeLa cells using KLF1 mouse mAb (green) and negative control (red).
说明书	Product Datasheet Protocol
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