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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > Monoclonal Antibodies > SHH / Sonic Hedgehog Antibody (clone 8G3)

SHH / Sonic Hedgehog Antibody (clone 8G3)

货号 货期 规格 / 价格 询价
APR09927G 50 μl / ¥4950

SHH / Sonic Hedgehog Antibody (clone 8G3)

品牌

Leading Biology

货号

APR09927G

产品分类

Monoclonal Antibodies

研究领域

产品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SHH / Sonic Hedgehog antibody (clone 8G3).

分子量

50kDa

细胞定位

Antigen Cellular Localization: Sonic hedgehog protein C-product: Secreted, extracellular space. Note=The C-terminal peptide diffuses from the cell.

宿主

Mouse

种属反应性

Human

靶点

Human Sonic Hedgehog / SHH

克隆号

8G3

基因ID

UniProt ID

功能

Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior- posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity).

总结

Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior- posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity).

形式

Liquid. In PBS containing 0.02% sodium azide.

储存条件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

应用

WB, IHC-P, E

稀释方法

ELISA (1:10000), IHC-P (1:200), WB (1:500-1:2000)

别名

Sonic hedgehog protein, SHH, HHG-1, Sonic hedgehog protein N-product, Sonic hedgehog protein C-product, SHH

图像

Anti-Sonic Hedgehog / SHH antibody IHC staining of human brain, cerebellum.

说明书

数量

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