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> 抗原抗体、ELISA、WB > 一抗 > Monoclonal Antibodies > Myelin Basic Protein / MBP Antibody (N-Terminus, clone V/h5)品牌 |
Leading Biology | 货号 |
AMM06522G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Myelin Basic Protein / MBP antibody (N-Terminus, clone V/h5).
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分子量 |
33kDa
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细胞定位 |
Antigen Cellular Localization:
Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin
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宿主 |
Mouse
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种属反应性 |
Human, Rabbit, Sheep, Bovine, Guinea Pig
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靶点 |
Recognizes predominantly residues 45-91
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克隆号 |
V/h5
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基因ID |
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UniProt ID |
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功能 |
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
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总结 |
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
IHC-P, E, RIA
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稀释方法 |
IHC-P (10 μg/ml)
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别名 |
Myelin basic protein, MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein, MBP
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图像 |
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说明书 |
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数量 |
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