全部产品分类
品牌 |
Leading Biology | 货号 |
APR17741G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PAG1 antibody (C-Terminus, clone PAG-C1).
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分子量 |
47kDa
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细胞定位 |
Antigen Cellular Localization:
Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts
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宿主 |
Mouse
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种属反应性 |
Human, Mouse, Rat, Bovine
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靶点 |
Recognizes an epitope located in the C-terminal domain of Csk-binding protein (Cbp / PAG), a 46 kD ubiquitously expressed transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which however migrates on SDS ...
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克隆号 |
PAG-C1
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通用名 |
CBP, PAG
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基因ID |
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UniProt ID |
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功能 |
Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
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总结 |
Negatively regulates TCR (T-cell antigen receptor)- mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
IHC-P, IP
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稀释方法 |
IHC-P (15 μg/ml)
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别名 |
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Csk-binding protein, Transmembrane adapter protein PAG, Transmembrane phosphoprotein Cbp, PAG1, CBP, PAG
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图像 |
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说明书 |
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数量 |
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