全部产品分类
品牌 |
Leading Biology | 货号 |
APG01581G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Adiponectin antibody (Clone MADI-1147).
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分子量 |
26809 Da
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细胞定位 |
Antigen Cellular Localization:
Secreted.
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宿主 |
Mouse
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种属反应性 |
Human, Mouse, Rat
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靶点 |
Adiponectin
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克隆号 |
MADI-1147
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亚型 |
Mouse IgG1
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通用名 |
Acdc, Acrp30, Apm1
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基因ID |
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UniProt ID |
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功能 |
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
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总结 |
Adipocytes are highly active cells with potent autocrine, paracrine, and endocrine functions. Adiponectin is a serum protein produced and secreted exclusively by adipose tissues. Unlike insulin and leptin, adiponectin levels in plasma remain constant thro μghout the day and are not acutely affected by food intake.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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别名 |
ACDC , ACRP30 , Acrp30, AdipoQ
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说明书 |
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数量 |
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