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> 抗原抗体、ELISA、WB > 一抗 > Monoclonal Antibodies > CD53 (TSPAN25) Antibody - Without BSA and Azide品牌 |
Leading Biology | 货号 |
APR14456G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CD53 (TSPAN25) antibody - Without BSA and Azide.
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分子量 |
33-55kDa
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细胞定位 |
Antigen Cellular Localization:
Cell membrane. Cell junction. Membrane; Multi-pass membrane protein Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes
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宿主 |
Mouse
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种属反应性 |
Human
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克隆号 |
161-2
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亚型 |
Mouse / IgG2a, kappa
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通用名 |
MOX44, TSPAN25
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基因ID |
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UniProt ID |
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功能 |
Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).
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总结 |
Recognizes a protein of 33-55kDa, identified as CD53 (Workshop VI; Code N-L033). It is expressed on monocytes and macrophages, dendritic cells, osteoblasts and osteoclasts, and on T and B cells from every stage of differentiation but is absent from platelets, red blood cells. CD53 appears to be the marker with widest reactivity as well as the marker with the strictest specificity to hematopoietic cells. CD53 is a type III membrane with both termini in the cytoplasm and two loops in the extracellular environment. This molecule, in common with other members of tetraspan family, is involved in cellular activation as part of a signal transduction complex involving other membrane glycoproteins. CD53 crosslinking induces calcium flux on human monocyte and B cells. Cross-linking of CD53 promotes activation of resting human B-lymphocytes. This MAb recognizes CD53 transfected cells and partially inhibits T-cell proliferation induced by CD3 antibody (clone: UCHT1).
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
IF, FC
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别名 |
Leukocyte surface antigen CD53, Cell surface glycoprotein CD53, Tetraspanin-25, Tspan-25, CD53, CD53, MOX44, TSPAN25
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说明书 |
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数量 |
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