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Leading Biology | 货号 |
APG01283G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TGF-beta (Transforming Growth Factor beta) antibody - Without BSA and Azide.
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分子量 |
13kDa
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细胞定位 |
Antigen Cellular Localization:
Secreted, extracellular space, extracellular matrix
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宿主 |
Mouse
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种属反应性 |
Human, Mouse, Hamster, Monkey, Cow, Dog
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克隆号 |
1D11.16.8
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亚型 |
Mouse / IgG1, kappa
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通用名 |
TGFB
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基因ID |
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UniProt ID |
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功能 |
Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.
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总结 |
This MAb recognizes TGF beta 1, 2 and 3. Three TGF? ?s have been identified in mammals. TGF? ?1, TGF? ?2 and TGF? ?3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF? ? requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF? ?3 protein has approximately 80% identity to the mature region of both TGF? ?1 and TGF? ?2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGF? ?ā€?s inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.?
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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别名 |
Transforming growth factor beta-1, TGF-beta-1, Latency-associated peptide, LAP, TGFB1, TGFB
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说明书 |
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数量 |
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