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> 抗原抗体、ELISA、WB > 一抗 > Monoclonal Antibodies > Thymidylate Synthase (5-FU Resistance Marker) Antibody品牌 |
Leading Biology | 货号 |
APG01286G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Thymidylate Synthase (5-FU Resistance Marker) antibody.
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分子量 |
36kDa
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Mitochondrion. Mitochondrion matrix. Mitochondrion inner membrane
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宿主 |
Mouse
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种属反应性 |
Human
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克隆号 |
SPM453
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亚型 |
Mouse / IgG1, kappa
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通用名 |
TS
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基因ID |
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UniProt ID |
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功能 |
Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
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总结 |
It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
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形式 |
Liquid. In PBS containing 0.02% sodium azide.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
IHC, IF, FC
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别名 |
Thymidylate synthase, TS, TSase, 2.1.1.45, TYMS, TS
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图像 |
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说明书 |
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数量 |
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