全部产品分类
品牌 |
Leading Biology | 货号 |
APR15168G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality BRAP antibody.
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分子量 |
67 KDa
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm.
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宿主 |
Mouse
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种属反应性 |
Human
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通用名 |
RNF52
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基因ID |
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UniProt ID |
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功能 |
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto- polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
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总结 |
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto- polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
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形式 |
Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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稀释方法 |
WB~~1:1000
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别名 |
3010002G07Rik;BRAP2;BRCA1 associated protein;EC 6.3.2.;Galectin 2 binding protein;IMP; Impedes mitogenic signal propagation;Renal carcinoma antigen NY REN 63; RING finger protein 52;RNF52;zgc:92894.
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图像 |
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说明书 |
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数量 |
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