全部产品分类
品牌 |
Leading Biology | 货号 |
AMM08790G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TIF1 gamma / TRIM33 antibody.
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分子量 |
140 KDa
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Note=In discrete nuclear dots resembling nuclear bodies.
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宿主 |
Mouse
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种属反应性 |
Human
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通用名 |
KIAA1113, RFG7, TIF1G
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基因ID |
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UniProt ID |
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功能 |
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade).
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总结 |
Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade).
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形式 |
Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.02% sodium azide, 50%,glycerol
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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稀释方法 |
WB~~1:1000
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别名 |
8030451N04Rik;AI413936;cb1085;DKFZp586K1123;E3 ubiquitin-protein ligase TRIM33;EC 6.3.2.-;Ectodermin;Ectodermin homolog;FLJ11429;FLJ32925;id:ibd2175;MGC136680;mKIAA1113; OTTHUMP00000013662;OTTHUMP00000013663;Protein Rfg7;PTC7;Ret fused gene 7;RET-fused gene 7 protein;RFG7;Rfg7 protein;TF1G;TIF1-gamma;TIF1G;TIF1GAMMA;TIFGAMMA;Transcription intermediary factor 1-gamma;Transcriptional intermediary factor 1 gamma;TRI33_HUMAN; Trim33;Tripartite motif containing 33;Tripartite motif containing 33 protein;tripartite motif-containing 33;Tripartite motif-containing protein 33;wu:fc17f10;zgc:136680.
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图像 |
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说明书 |
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数量 |
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