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PINK1 Antibody (Ascites)

AMR09287G Product Datasheet Protocol

货号	货期	规格 / 价格	询价
AMR09287G		0.1 ml / ￥4950

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PINK1 Antibody (Ascites)

品牌	Leading Biology	货号	AMR09287G
产品分类	Monoclonal Antibodies	研究领域
产品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PINK1 antibody (Ascites).
分子量	62769 Da
细胞定位	Antigen Cellular Localization: Mitochondrion outer membrane; Single-pass membrane protein. Cytoplasm, cytosol
宿主	Mouse
种属反应性	Human, Mouse
靶点	Recombinant PINK1 protein was used to produced this monoclonal antibody.
克隆号	38CT20.8.5
亚型	IgG1
基因ID	65018
UniProt ID	Q9BXM7
功能	Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582).
总结	This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease.
形式	Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
储存条件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
应用	WB, IHC-P, E
稀释方法	WB~~1:500~2000 IHC-P~~1:10~50
别名	Serine/threonine-protein kinase PINK1, mitochondrial, BRPK, PTEN-induced putative kinase protein 1, PINK1
图像	Western blot analysis of anti-PINK1 Monoclonal Antibody (AMR09287G) in mouse brain tissue lysates. PINK1(arrow) was detected using the ascites Mab. (dilution 1:500) Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with PINK1 Monoclonal Antibody (Cat. AMR09287G), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Formalin-fixed and paraffin-embedded human Brain Cortex tissue reacted with PINK1 Monoclonal Antibody (Cat. AMR09287G), which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
说明书	Product Datasheet Protocol
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