全部产品分类
品牌 |
Leading Biology | 货号 |
APR15940G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality FCGR3A antibody (Ascites).
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分子量 |
29089 Da
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细胞定位 |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein. Secreted. Note=Exists also as a soluble receptor
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宿主 |
Mouse
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种属反应性 |
Human
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免疫原 |
60-88 aa
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靶点 |
This FCGR3A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 60-88 amino acids from human FCGR3A.
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克隆号 |
441CT4.2.1
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亚型 |
IgG1
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通用名 |
CD16A, FCG3, FCGR3, IGFR3
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基因ID |
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UniProt ID |
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功能 |
Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
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总结 |
This gene encodes a receptor for the Fc portion ofimmunoglobulin G, and it is involved in the removal ofantigen-antibody complexes from the circulation, as well as otherother antibody-dependent responses. This gene (FCGR3A) is highlysimilar to another nearby gene (FCGR3B) located on chromosome 1.The receptor encoded by this gene is expressed on natural killer(NK) cells as an integral membrane glycoprotein anchored through atransmembrane peptide, whereas FCGR3B is expressed onpolymorphonuclear neutrophils (PMN) where the receptor is anchoredthrough a phosphatidylinositol (PI) linkage. Mutations in this genehave been linked to susceptibility to recurrent viral infections,susceptibility to systemic lupus erythematosus, and alloimmuneneonatal neutropenia. Alternatively spliced transcript variantsencoding different isoforms have been found for this gene.
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形式 |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:100~400
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别名 |
Low affinity immunoglobulin gamma Fc region receptor III-A, CD16a antigen, Fc-gamma RIII-alpha, Fc-gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc receptor III-2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3
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图像 |
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说明书 |
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数量 |
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