全部产品分类
品牌 |
Leading Biology | 货号 |
APR10568G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TSC1 antibody (Ascites).
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分子量 |
129767 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state found in association with membranes
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宿主 |
Mouse
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种属反应性 |
Mouse
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靶点 |
Purified His-tagged TSC1 protein(Fragment) was used to produced this monoclonal antibody.
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克隆号 |
357CT4.4.2
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亚型 |
IgG2b
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通用名 |
KIAA0243, TSC
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基因ID |
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UniProt ID |
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功能 |
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.
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总结 |
This gene encodes a growth inhibitory protein thought toplay a role in the stabilization of tuberin. Mutations in this genehave been associated with tuberous sclerosis. Alternative splicingresults in multiple transcript variants.
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形式 |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:500~8000
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别名 |
Hamartin, Tuberous sclerosis 1 protein, TSC1, KIAA0243, TSC
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图像 |
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说明书 |
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数量 |
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