全部产品分类
品牌 |
Leading Biology | 货号 |
APR07668G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality EIF4EBP1 antibody (ascites).
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分子量 |
12580 Da
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宿主 |
Mouse
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种属反应性 |
Human
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靶点 |
This EIF4EBP1 monoclonal antibody is generated from mouse immunized with EIF4EBP1 recombinant protein.
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克隆号 |
319CT22.8.2
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亚型 |
IgG1
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基因ID |
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UniProt ID |
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功能 |
Regulates eIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
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总结 |
This gene encodes one member of a family of translationrepressor proteins. The protein directly interacts with eukaryotictranslation initiation factor 4E (eIF4E), which is a limitingcomponent of the multisubunit complex that recruits 40S ribosomalsubunits to the 5' end of mRNAs. Interaction of this protein witheIF4E inhibits complex assembly and represses translation. Thisprotein is phosphorylated in response to various signals includingUV irradiation and insulin signaling, resulting in its dissociationfrom eIF4E and activation of mRNA translation. [provided byRefSeq].
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形式 |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:500~8000
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别名 |
Eukaryotic translation initiation factor 4E-binding protein 1, 4E-BP1, eIF4E-binding protein 1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, PHAS-I, EIF4EBP1
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图像 |
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说明书 |
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数量 |
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