全部产品分类
品牌 |
Leading Biology | 货号 |
APR12739G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PAX6 antibody (Ascites).
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分子量 |
46683 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus.
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宿主 |
Mouse
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种属反应性 |
Human
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靶点 |
This PAX6 Monoclonal antibody was raised using purified His-tagged recombinant human PAX6.
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克隆号 |
193CT15.2.2
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亚型 |
IgM,K
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通用名 |
AN2
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基因ID |
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UniProt ID |
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功能 |
Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes.
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总结 |
This gene encodes paired box gene 6, one of many humanhomologs of the Drosophila melanogaster gene prd. In addition tothe hallmark feature of this gene family, a conserved paired boxdomain, the encoded protein also contains a homeo box domain. Bothdomains are known to bind DNA, and function as regulators of genetranscription. This gene is expressed in the developing nervoussystem, and in developing eyes. Mutations in this gene are known tocause ocular disorders such as aniridia and Peter's anomaly.Alternatively spliced transcript variants encoding either the sameor different isoform have been found for this gene. [provided byRefSeq].
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形式 |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IF, E
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稀释方法 |
WB~~1:500~16000
IF~~1:10~50
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别名 |
Paired box protein Pax-6, Aniridia type II protein, Oculorhombin, PAX6, AN2
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图像 |
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说明书 |
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数量 |
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