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> 抗原抗体、ELISA、WB > 一抗 > Monoclonal Antibodies > Cytokeratin, Basic (Type II or HMW) (Epithelial Marker) Antibody - With BSA and Azide品牌 |
Leading Biology | 货号 |
APR14607G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Cytokeratin, Basic (Type II or HMW) (Epithelial Marker) antibody - With BSA and Azide.
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分子量 |
52-67kDa
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细胞定位 |
Antigen Cellular Localization:
Cell membrane. Note=Located on plasma membrane of neuroblastoma NMB7 cells
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宿主 |
Mouse
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种属反应性 |
Human, Mouse, Rat
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靶点 |
Solubilized keratin extract from human stratum corneum
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克隆号 |
AE-3
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亚型 |
IgG1
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通用名 |
KRTA
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基因ID |
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UniProt ID |
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功能 |
May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.
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总结 |
This MAb recognizes basic (Type II or HMW) cytokeratins, which include 67kDa (CK1); 64kDa (CK3); 59kDa (CK4); 58kDa (CK5); 56kDa (CK6); 52kDa (CK8). Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. The acidic keratins have molecular weights (MW) of 56.5, 55, 51, 50, 50’, 48, 46, 45, and 40kDa. MAb AE3 recognizes the 65-67, 64, 59, 58, 56, and 52kDa keratins of basic subfamily. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE1/AE3 is a broad spectrum anti pan-keratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer.
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形式 |
0.5 ml at 200ug/ml with BSA and azide
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC, FC, IP, E
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别名 |
Keratin, type II cytoskeletal 1, 67 kDa cytokeratin, Cytokeratin-1, CK-1, Hair alpha protein, Keratin-1, K1, Type-II keratin Kb1, KRT1, KRTA
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图像 |
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说明书 |
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数量 |
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