全部产品分类
品牌 |
Leading Biology | 货号 |
APR10256G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Stat-5 antibody Phospho (pY694).
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分子量 |
90647 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse
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靶点 |
A synthetic phospho-peptide corresponding to residues surrounding Tyr694 of human Stat5 was used as immunogen. The antibody only detects Stat5 phosphorylated on Tyrosine 694.
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克隆号 |
E208
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通用名 |
STAT5
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基因ID |
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UniProt ID |
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功能 |
Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.
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总结 |
Signal transducer and activator of transcription 5 (Stat5) functions both in signal transduction and activation of transcription. It has been found that cytoplasmic Stat5 is translocated to the nucleus in response to phosphorylation. Stat5 is tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL-15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin (1,2). Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity. NCoA-1/SRC-1 acts as a coactivator for both the a- and b-isoforms of Stat5 (3).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC
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稀释方法 |
WB~~1:1000~10000
IHC~~1:50
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别名 |
Signal transducer and activator of transcription 5A, STAT5A, STAT5
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图像 |
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说明书 |
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数量 |
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