> 抗原抗体、ELISA、WB > 一抗 > Monoclonal Antibodies > Serum amyloid Antibodies P-Component (N-term)品牌 |
Leading Biology | 货号 |
APR13293G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Serum amyloid Antibodies P-Component (N-term).
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分子量 |
25387 Da
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细胞定位 |
Antigen Cellular Localization:
Secreted.
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宿主 |
Rabbit
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种属反应性 |
Human
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靶点 |
A synthetic peptide corresponding to residues near the N-term of human SAP was used as an immunogen.
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克隆号 |
EP1018Y
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通用名 |
PTX2
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基因ID |
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UniProt ID |
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功能 |
Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.
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总结 |
Serum Amyloid P (SAP) is a non-fibrillar plasma glycoprotein that belongs to the pentraxin family. It is universally found in amyloid deposits and this is probably due to its specific calcium-dependent binding to motifs present on all types of amyloid fibrils. SAP is also found to prevent fibrillar breakdown by enzymes and it is believed that it helps maintains stability of the amyloid deposits (1,2). It has been shown that SAP binds monocytes with high avidity, but does not bind to erythrocytes, NK cells, T lymphocytes or B lymphocytes (3). SAP production can be induced by exposure to IL-1, IL-6 and IFN-beta. The SAP-inducing activity was neutralized by antibodies to each of the recombinant cytokines (4).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC
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稀释方法 |
WB~~1:10000~50000
IHC~~1:100~250
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别名 |
Serum amyloid P-component, SAP, 95S alpha-1-glycoprotein, Serum amyloid P-component(1-203), APCS, PTX2
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图像 |
A. Western blot analysis on human serum membrane using anti-SAP RabMAb (Cat. APR13293G), dilution 1:1,000,000.
B. Immunohistochemical staining of paraffin-embedded human kidney using anti-SAP RabMAb (Cat. APR13293G). |
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说明书 |
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数量 |
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