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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > Monoclonal Antibodies > Serum amyloid Antibodies P-Component (N-term)

Serum amyloid Antibodies P-Component (N-term)

货号 货期 规格 / 价格 询价
APR13293G 100 μl / ¥5450

Serum amyloid Antibodies P-Component (N-term)

品牌

Leading Biology

货号

APR13293G

产品分类

Monoclonal Antibodies

研究领域

产品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Serum amyloid Antibodies P-Component (N-term).

分子量

25387 Da

细胞定位

Antigen Cellular Localization: Secreted.

宿主

Rabbit

种属反应性

Human

靶点

A synthetic peptide corresponding to residues near the N-term of human SAP was used as an immunogen.

克隆号

EP1018Y

通用名

PTX2

基因ID

UniProt ID

功能

Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin.

总结

Serum Amyloid P (SAP) is a non-fibrillar plasma glycoprotein that belongs to the pentraxin family. It is universally found in amyloid deposits and this is probably due to its specific calcium-dependent binding to motifs present on all types of amyloid fibrils. SAP is also found to prevent fibrillar breakdown by enzymes and it is believed that it helps maintains stability of the amyloid deposits (1,2). It has been shown that SAP binds monocytes with high avidity, but does not bind to erythrocytes, NK cells, T lymphocytes or B lymphocytes (3). SAP production can be induced by exposure to IL-1, IL-6 and IFN-beta. The SAP-inducing activity was neutralized by antibodies to each of the recombinant cytokines (4).

形式

50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

储存条件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

应用

WB, IHC

稀释方法

WB~~1:10000~50000 IHC~~1:100~250

别名

Serum amyloid P-component, SAP, 95S alpha-1-glycoprotein, Serum amyloid P-component(1-203), APCS, PTX2

图像

A. Western blot analysis on human serum membrane using anti-SAP RabMAb (Cat. APR13293G), dilution 1:1,000,000.

B. Immunohistochemical staining of paraffin-embedded human kidney using anti-SAP RabMAb (Cat. APR13293G).

说明书

数量

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