全部产品分类
品牌 |
Leading Biology | 货号 |
AMR09561G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Prostaglandin-E Synthase 3 antibody.
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分子量 |
18697 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm.
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
A synthetic peptide corresponding to residues in human Prostaglandin E Synthase 3 was used as an immunogen.
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克隆号 |
EPR3846
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通用名 |
P23, TEBP
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基因ID |
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UniProt ID |
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功能 |
Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448).
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总结 |
Prostaglandin E synthase-3 belongs to p23/wos2 family. It is ubiquitously expressed. As one of the two isoforms of the terminal enzymes catalyzing the final step of EG2 biosynthesis, prostaglandin E synthase-3 predominantly converts COX-1-derived PGH2 to PGE2 (1). It is an evolutionarily conserved protein that functions as a component of the Hsp90-based molecular chaperone complex (2). It binds to telomerase and to the progesterone receptor (3). It localizes to genomic response elements in a hormone-dependent manner and represses receptor-mediated transcriptional activation by promoting disassembly of transcriptional regulatory complexes (4).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IF
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稀释方法 |
WB~~1:100000
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别名 |
Prostaglandin E synthase 3, Cytosolic prostaglandin E2 synthase, cPGES, Hsp90 co-chaperone, Progesterone receptor complex p23, Telomerase-binding protein p23, PTGES3, P23, TEBP
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图像 |
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说明书 |
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数量 |
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