全部产品分类
品牌 |
Leading Biology | 货号 |
AMR09556G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Prohibitin antibody (C-term).
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分子量 |
29804 Da
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细胞定位 |
Antigen Cellular Localization:
Mitochondrion inner membrane.
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
A synthetic peptide corresponding to residues in human prohibitin was used as an immunogen.
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克隆号 |
EP2804Y
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基因ID |
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UniProt ID |
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功能 |
Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.
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总结 |
Prohibitin (PHB) proteins have been ascribed various functions, including cell cycle regulation, apoptosis, assembly of mitochondrial respiratory chain enzymes, and aging. It has been shown that the mammalian prohibitins are present in the inner mitochondrial membrane and are always bound to each other, with no free protein detectable. They are coexpressed during development and in adult mammalian tissues, and expression levels are indicative of a role in mitochondrial metabolism, but are not compatible with roles in the regulation of cellular proliferation or apoptosis. Data support conserved roles for the prohibitins in regulating mitochondrial respiratory activity and in aging (1). Results suggest that prohibitin may be a tumor suppressor and is associated with tumor development and/or progression of at least some breast cancers (2).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC, IF
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稀释方法 |
WB~~1:1000~2000
IHC~~1:100~250
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别名 |
Prohibitin, PHB
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图像 |
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说明书 |
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数量 |
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