全部产品分类
品牌 |
Leading Biology | 货号 |
AMM07264G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PP2C alpha antibody.
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分子量 |
42448 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm, cytosol. Membrane. Note=Weakly associates at the membrane and N- myristoylation mediates the membrane localization.
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
A synthetic peptide corresponding to residues near the C-terminal of human PP2C alpha protein was used as an immunogen.
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克隆号 |
EP1684Y
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通用名 |
PPPM1A
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基因ID |
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UniProt ID |
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功能 |
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
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总结 |
Protein phosphatase 2C (PP2C) is a family of serine/threonine specific protein phosphatases. PP2C is a 42 kDa monomeric enzyme with broad substrate specificity and its activity is depended upon divalent cations (e.g. magnesium) (1). In mammals, three members of PP2C family are known; PP2C -alpha, -beta, and -gamma. PP2C-alpha functions by dephosphorylating various substrates (e.g. Smad1, MAPK) and it is considered to be a negative regulator of cell stress pathway (2). PP2C-alpha has been implicated in the regulation of apoptosis-, p53-, cyclin-dependent kinase-, and TGF beta- signaling. Studies have suggested tumor-suppressing properties of PP2C -alpha and its possible role in cancer development and progression (3).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC
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稀释方法 |
WB~~1:10000~50000
IHC~~1:100~250
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别名 |
Protein phosphatase 1A, Protein phosphatase 2C isoform alpha, PP2C-alpha, Protein phosphatase IA, PPM1A, PPPM1A
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图像 |
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说明书 |
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数量 |
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