全部产品分类
品牌 |
Leading Biology | 货号 |
AMM06722G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
|
产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NMDAR2B antibody Phospho (pS1303).
|
||
分子量 |
166367 Da
|
||
细胞定位 |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein
|
||
宿主 |
Rabbit
|
||
种属反应性 |
Human, Mouse
|
||
靶点 |
A phospho specific peptide corresponding to residues surrounding serine 1303 of human NMDAR2B was used as an immunogen. This antibody detects NMDAR2B phosphorylated at serine 1303.
|
||
克隆号 |
EP1858Y
|
||
通用名 |
NMDAR2B
|
||
基因ID |
|||
UniProt ID |
|||
功能 |
NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity).
|
||
总结 |
The NMDA (N-methyl D-aspartate) receptors in the brain play a critical role in synaptic plasticity, synaptogenesis and excitotoxicity. NMDA R1 and combination of one or more NMDAR2 subunits forms NMDA receptor glutamate-gated ion channels. In this hetromer complex, NMDA R1 binds to co-agonist glycine and NMDA R2 binds to neurotransmitter glutamate (1). Several studies have suggested that protein phosphorylation of NMDA receptors may affect channel function, and additionally regulate these receptors? synaptic trafficking and surface expression. Once activated thru phospholyation, these channels allow movement of Ca2+ and Na+ into the cell and K+ out of the cell. Serine 1303 on NMDAR2B has been identified as a major phospholyation site for CaM kinase II and PKC, regulating kinase-mediated NMNDAR2B/R1 current (2,3). NMDAR has been linked to various neurodegenerative disorders such as schizophrenia, epilepsy, and Alzheimer's disease (4).
|
||
形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
|
||
储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
|
||
应用 |
WB
|
||
稀释方法 |
WB~~1:1000~5000
|
||
别名 |
Glutamate receptor ionotropic, NMDA 2B, GluN2B, Glutamate [NMDA] receptor subunit epsilon-2, N-methyl D-aspartate receptor subtype 2B, NMDAR2B, NR2B, N-methyl-D-aspartate receptor subunit 3, NR3, hNR3, GRIN2B, NMDAR2B
|
||
图像 |
|
||
说明书 |
|||
数量 |
|
||
| 选择 | 品牌 | 货号 | 产品名称 | 规格 | 分类 | 研究领域 | 说明书 | 数量 | 目录价 | |
| 1 | Leading Biology | APG01369G | VEGF (Vascular Endothelial Growth Factor) Antibody - Without BSA and Azide | 100 μg | Monoclonal Antibodies |
|
￥4950.00 | 订购 询价 | ||
| 2 | Leading Biology | AMM07627G | RIN2 Antibody (monoclonal) (M01) | 100 μg | Monoclonal Antibodies |
|
￥4950.00 | 订购 询价 | ||
| 3 | Leading Biology | APR15980G | FGG Antibody | 100 μl | Monoclonal Antibodies |
|
￥5450.00 | 订购 询价 | ||
| 4 | Leading Biology | AMM05161G | GOB5 / CLCA1 Antibody (clone 1C4) | 50 μg | Monoclonal Antibodies |
|
￥5450.00 | 订购 询价 | ||
| 5 | Leading Biology | APR11118G | HIV-1 p24 Antibody [7F4] (biotin) | 0.1 mg | Monoclonal Antibodies |
|
￥6950.00 | 订购 询价 | ||
| 6 | Leading Biology | APR17667G | ORAI1 Antibody [3F6H5] | 0.1 mg | Monoclonal Antibodies |
|
￥6950.00 | 订购 询价 |
微信扫描二维码，随时随地与小诺亲密接触，精彩活动，劲爆优惠，触手可得！
销售-华东区