全部产品分类
品牌 |
Leading Biology | 货号 |
AMM06663G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NF-H antibody.
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分子量 |
112479 Da
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
A synthetic peptide corresponding to residues in human NF-H was used as immunogen.
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克隆号 |
EP673Y
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通用名 |
KIAA0845, NFH
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基因ID |
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UniProt ID |
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功能 |
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.
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总结 |
Neurofilaments (NF) are members of the intermediate filament protein family also known as 10nm filaments. These neuron-specific filaments are the major constituents of the axonal cytoskeleton (1). NFs are composed of three major proteins; NF-H, NF-L and NF-M and the ratio of each protein changes during neuronal development. NF-H is the heavy molecular weight protein (200 kDa), NF-M the medium (160 kDa) and NF-L the light protein (68kDa) (2). Phosphorylation of the NF-H tail domain modulates neurofilament transport, dynamics and organization within the axon. Accumulation of the protein or mutations in NF-H is observed during the progression of numerous neurological diseases such as amyotrophic lateral sclerosis (3).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC, IF
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稀释方法 |
WB~~1:500~2000
IHC~~1:500
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别名 |
Neurofilament heavy polypeptide, NF-H, 200 kDa neurofilament protein, Neurofilament triplet H protein, NEFH, KIAA0845, NFH
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图像 |
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说明书 |
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数量 |
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