全部产品分类
品牌 |
Leading Biology | 货号 |
APR07966G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality IL-15 antibody.
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分子量 |
18086 Da
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细胞定位 |
Antigen Cellular Localization:
Isoform IL15-S48AA: Secreted.
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宿主 |
Rabbit
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种属反应性 |
Human
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靶点 |
A recombinant human IL-15 was used an immunogen.
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克隆号 |
EPR1542Y
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基因ID |
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UniProt ID |
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功能 |
Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.
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总结 |
Interleukin 15 (IL-15) is a cytokine that shares many biological activities with IL-2. Both cytokines interact with the β and γ component of the IL-2 receptor. However, unlike IL-2 which is secreted only by T cells, IL-15 is expressed preferentially by nonlymphoid tissues, epithelial, and fibroblast cell lines (1). Two isoforms of human IL-15 are known. The longer form is localized to the plasma membrane or may be secreted, while the other (the shorter form) is found within the cytoplasm and the nucleus (2). IL-15 regulates T and natural killer cell activation and proliferation, causes B cell proliferation and differentiation and stimulates chemotaxis of T cells (3-4). It also induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. High concentrations of IL-15 have been observed in inflamed joints of rheumatoid arthritis patients, suggesting a role for IL-15 in inflammatory diseases where there is recruitment of leukocytes (5).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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稀释方法 |
WB~~1:500
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别名 |
Interleukin-15, IL-15, IL15
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图像 |
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说明书 |
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数量 |
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