全部产品分类
品牌 |
Leading Biology | 货号 |
AMM04527G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Ferritin antibody (heavy chain).
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分子量 |
21226 Da
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宿主 |
Rabbit
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种属反应性 |
Human
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靶点 |
A synthetic peptide corresponding to residues near the C terminus of human Ferritin (heavy chain) was used as an immunogen. This antibody recognizes only the Ferritin heavy chain.
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克隆号 |
EPR3005Y
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通用名 |
FTH, FTHL6
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基因ID |
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UniProt ID |
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功能 |
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
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总结 |
Ferritin is important in iron homeostasis. It is the main iron-storage protein, composed of two partially homologous subunits, heavy and light chains. Ferritin molecules in cells containing high levels of iron tend to be rich in light chains, and may have a long-term storage function, whereas heavy-rich ferritins are more active in iron metabolism (1-2). Mutations in the ferritin gene cause the hereditary hyperferritinemia-cataract syndrome and neuroferritinopathy, associated with inflammation. Elevated levels of ferritin are reported as characteristic of adult-onset Still's disease and hemophagocytic syndrome, also associated with inflammation (3). Microfilaments and increased levels of exogenous ferritin are excreted directly into the bile by way of a second microfilament-independent, chloroquine-insensitive pathway, supporting a possible physiological mechanism for the release of ferritin from the liver (4).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC
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稀释方法 |
WB~~1:500~2000
IHC~~1:100~250
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别名 |
Ferritin heavy chain, Ferritin H subunit, Cell proliferation-inducing gene 15 protein, Ferritin heavy chain, N-terminally processed, FTH1, FTH, FTHL6
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图像 |
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说明书 |
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数量 |
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