全部产品分类
品牌 |
Leading Biology | 货号 |
APR11644G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality COPS3 antibody.
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分子量 |
47873 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus
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宿主 |
Rabbit
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种属反应性 |
Human, Mouse, Rat
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靶点 |
A synthetic peptide corresponding to residues at the C-terminus of human COPS3 was used as an immunogen.
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克隆号 |
EPR3127
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通用名 |
CSN3
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基因ID |
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UniProt ID |
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功能 |
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
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总结 |
COPS3 is a component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. Individual subunits of the complex have been linked to various signal transduction pathways leading to gene expression and cell cycle control (1, 2). Subunit 3 (COPS3) possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-B alpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation (3). COPS3 is suggested as a specific negative regulator of TNF-induced NF-kappaB activation pathways because its over-expression inhibits NF-kappaB activation (4).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IF
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稀释方法 |
WB~~1:1000~10000
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别名 |
COP9 signalosome complex subunit 3, SGN3, Signalosome subunit 3, JAB1-containing signalosome subunit 3, COPS3, CSN3
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图像 |
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说明书 |
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数量 |
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