全部产品分类
品牌 |
Leading Biology | 货号 |
APR11554G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Calpactin-I antibody (light chain).
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分子量 |
11203 Da
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宿主 |
Rabbit
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种属反应性 |
Human
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靶点 |
A synthetic peptide corresponding to residues in human Calpactin I light chain/S100A10 was used as an immunogen.
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克隆号 |
EPR3317
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通用名 |
ANX2LG, CAL1L, CLP11
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基因ID |
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UniProt ID |
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功能 |
Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine- specific kinase.
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总结 |
S100 proteins are low-molecular-weight calcium-binding proteins of the EF-hand superfamily and appear to be involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation (1). The Calpactin I light chain (S100 calcium-binding protein A10; S100A10) is a member of the S100 family and it forms a heterotetrameric complex with another calcium-binding protein, annexin II(2). S100A10 is present in basal and spinous cells, in the cytoplasm, and is associated with the plasma membrane (3). The basic unit for S100A10 is a tight, non-covalent dimmer (4). S100A10, as well as a few other members of the S100 family, are suggested as transglutaminase substrates. Also, S100 proteins have been reported to localize to the plasma membrane in differentiated keratinocytes, suggesting a role in regulating calcium-dependent, membrane-associated events (3).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC
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稀释方法 |
WB~~1:500~1000
IHC~~1:100~250
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别名 |
Protein S100-A10, Calpactin I light chain, Calpactin-1 light chain, Cellular ligand of annexin II, S100 calcium-binding protein A10, p10 protein, p11, S100A10, ANX2LG, CAL1L, CLP11
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图像 |
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说明书 |
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数量 |
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