全部产品分类
品牌 |
Leading Biology | 货号 |
APG02176G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Bag-1 antibody.
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分子量 |
38779 Da
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细胞定位 |
Antigen Cellular Localization:
Isoform 1: Nucleus. Cytoplasm. Note=Isoform 1 localizes predominantly to the nucleus Isoform 4: Cytoplasm. Nucleus. Note=Isoform 4 localizes predominantly to the cytoplasm. The cellular background in which it is expressed can influence whether it resides primarily in the cytoplasm or is also found in the nucleus. In the presence of BCL2, localizes to intracellular membranes (what appears to be the nuclear envelope and perinuclear membranes) as well as punctate cytosolic structures suggestive of mitochondria
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宿主 |
Rabbit
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种属反应性 |
Human, Rat
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靶点 |
A synthetic peptide corresponding to residues following the repeat 7 of human Bag-1 was used as immunogen. The antibody should recognize all three isoforms of Bag-1 (Bag-1L, Bag-1M and Bag-1S).
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克隆号 |
Y166
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通用名 |
HAP
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基因ID |
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UniProt ID |
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功能 |
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.
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总结 |
Members of the Bcl-2 family of proteins play varied stimulatory or inhibitory roles in the regulation of programmed cell death, or apoptosis. One member of this family, Bcl2-Interacting Protein-1 (BAG-1), functions in conjunction with Bcl-2 to inhibit apoptosis (1,2). BAG-1 is a heat shock 70 kDa (Hsp70)- binding protein (3) that is localized to either the cytosol, nucleus or both.
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC, IF
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稀释方法 |
WB~~1:1000~10000
IHC~~1:100~250
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别名 |
BAG family molecular chaperone regulator 1, BAG-1, Bcl-2-associated athanogene 1, BAG1, HAP
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图像 |
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说明书 |
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数量 |
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