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> 抗原抗体、ELISA、WB > 一抗 > Monoclonal Antibodies > Phospho-Ser294 Progesterone Receptor Antibody品牌 |
Leading Biology | 货号 |
AMM02581G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho-Ser294 Progesterone Receptor Antibody.
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分子量 |
90/120 KDa
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宿主 |
mouse
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种属反应性 |
Human
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靶点 |
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser294 conjugated to KLH.
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克隆号 |
608
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亚型 |
IgG1
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基因ID |
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UniProt ID |
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总结 |
There is accumulating evidence to suggest that progesteroneplaysan essential role in the regulation of growth and differentiationof mammary glands and thus mayplay a key role in breast cancer (Edwards, 2005). The biological response to progesterone ismediated by two distinct formsof the human progesterone receptor (PR-A and PR-B forms). Inmost cellcontexts, the B form functions as a transcriptional activator, whereas the A formfunctions as a transcriptionalinhibitor of steroid hormones (Attia et al., 2000; Lin et al., 2003).Recently it has been demonstrated that there is differential hormone dependent regulation of thephosphorylation of the A and B forms of the receptor (Clemm et al., 2000) . Treatment of T47Dbreast cancer cells with progestin agonist increases the phosphorylation of Ser190and Ser294with different kinetics. These phosphorylation events may differentially affect the transcriptionalactivity of the receptor.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB
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稀释方法 |
WB~~ 1:1000
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图像 |
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说明书 |
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数量 |
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