全部产品分类
品牌 |
Leading Biology | 货号 |
AMM02659G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality EphB3 Antibody.
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分子量 |
110330 Da
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细胞定位 |
Antigen Cellular Localization:
Cell membrane; Single-pass type I membrane protein Cell projection, dendrite
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宿主 |
Mouse
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种属反应性 |
Human
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克隆号 |
4A122D1
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亚型 |
IgG2a
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通用名 |
ETK2, HEK2, TYRO6
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基因ID |
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UniProt ID |
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功能 |
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC, E
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稀释方法 |
WB~~1/500 - 1/2000
IHC~~1/500 - 1/2000
ICC~~1:200~~1000
IF~~1:200~1000.
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图像 |
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说明书 |
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数量 |
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