> 抗原抗体、ELISA、WB > 一抗 > Monoclonal Antibodies > MCAM / CD146 Antibody (aa84-189, clone 6C3E6)品牌 |
Leading Biology | 货号 |
AMM02239G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MCAM / CD146 Antibody (aa84-189, clone 6C3E6).
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分子量 |
72kDa
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细胞定位 |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein
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宿主 |
Mouse
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种属反应性 |
Human
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靶点 |
Human MCAM / CD146
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克隆号 |
6C3E6
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通用名 |
MUC18
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基因ID |
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UniProt ID |
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功能 |
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
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总结 |
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC-P, E, Flo
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稀释方法 |
ELISA (1:10000), Flo (1:200-1:400), IHC-P (10 μg/ml), WB (1:500-1:2000) ,
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图像 |
Anti-MCAM / CD146 antibody IHC staining of human lung. |
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说明书 |
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数量 |
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