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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > Monoclonal Antibodies > KLHL12 Antibody

KLHL12 Antibody

货号 货期 规格 / 价格 询价
AMM02774G 100 μl / ¥4950

KLHL12 Antibody

品牌

Leading Biology

货号

AMM02774G

产品分类

Monoclonal Antibodies

研究领域

产品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality KLHL12 Antibody.

分子量

63kDa

细胞定位

Antigen Cellular Localization: Cytoplasmic vesicle, COPII-coated vesicle

宿主

Mouse

种属反应性

Human

克隆号

2G2

亚型

IgG1

通用名

C3IP1

基因ID

UniProt ID

功能

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport. The BCR(KLHL12) complex is involved in ER-Golgi transport by regulating the size of COPII coats, thereby playing a key role in collagen export, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B). As part of the BCR(KLHL12) complex, also acts as a negative regulator of the Wnt signaling pathway by mediating ubiquitination and subsequent proteolysis of DVL3. The BCR(KLHL12) complex also mediates polyubiquitination of DRD4, without leading to degradation of DRD4.

储存条件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

应用

WB, E

稀释方法

WB~~1/500 - 1/2000

图像

Figure 1: Western blot analysis using KLHL12 mouse mAb against Hela (1) cell lysate.

说明书

数量

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