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> 抗原抗体、ELISA、WB > 一抗 > Monoclonal Antibodies > Cyclin B1 (G2- & M-phase Cyclin) Antibody - Without BSA and Azide品牌 |
Leading Biology | 货号 |
AMM01438G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Cyclin B1 (G2- & M-phase Cyclin) Antibody - Without BSA and Azide.
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分子量 |
55-62kDa
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
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宿主 |
Mouse
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种属反应性 |
Human, Mouse
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克隆号 |
SPM619
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亚型 |
Mouse / IgG1, kappa
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通用名 |
CCNB
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基因ID |
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UniProt ID |
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功能 |
Essential for the control of the cell cycle at the G2/M (mitosis) transition.
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总结 |
It recognizes a protein of 55-62kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
IHC, IF, FC
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图像 |
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说明书 |
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数量 |
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