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> 抗原抗体、ELISA、WB > 一抗 > Monoclonal Antibodies > Transgelin (SM22-alpha) Antibody - Without BSA品牌 |
Leading Biology | 货号 |
AMM01352G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Transgelin (SM22-alpha) Antibody - Without BSA.
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分子量 |
22kDa
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm.
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宿主 |
Mouse
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种属反应性 |
Human, Mouse, Rabbit, Pig, Cow
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克隆号 |
SPM606
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亚型 |
Mouse / IgG1, kappa
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通用名 |
SM22, WS3-10
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基因ID |
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UniProt ID |
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功能 |
Actin cross-linking/gelling protein (By similarity). Involved in calcium interactions and contractile properties of the cell that may contribute to replicative senescence.
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总结 |
This MAb recognizes a 22kDa protein, identified as Transgelin, also designated SM22-alpha. It may cross-react with SM22-beta. Transgelin is expressed abundantly in smooth muscle cells. The human transgelin gene encodes a 201 amino acid protein that contains nuclear factor-binding motifs known to regulate transcription in smooth muscle. During embryogenesis, transgelin is expressed in smooth, cardiac and skeletal muscle, but is restricted during late fetal development and adulthood to all vascular and visceral smooth muscle cells and low levels of expression in heart. Transgelin is down regulated in several transformed cell lines, indicating that a reduction of transgelin expression may be an early indicator of the onset of transformation. Transgelin also binds Actin, causing Actin fibers to gel within minutes of binding. Binding of transgelin to Actin occurs at a ratio of 1:6 Actin monomers.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
IHC-P, IF, FC
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图像 |
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说明书 |
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数量 |
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