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> 抗原抗体、ELISA、WB > 一抗 > Monoclonal Antibodies > HLA-DQ (MHC II) Antibody - Without BSA and Azide品牌 |
Leading Biology | 货号 |
AMM00832G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality HLA-DQ (MHC II) Antibody - Without BSA and Azide.
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分子量 |
60kDa
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宿主 |
Mouse
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种属反应性 |
Human, Pig
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克隆号 |
SPV-L3
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亚型 |
Mouse / IgG2a, kappa
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UniProt ID |
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总结 |
Recognizes a DQ antigen, which is a dimer of 60kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.?This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones.
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形式 |
Liquid
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
IHC, IF, FC
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说明书 |
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数量 |
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