全部产品分类
品牌 |
Leading Biology | 货号 |
AMM02421G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality VDR Antibody.
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分子量 |
48289 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus.
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宿主 |
Mouse
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种属反应性 |
Human
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靶点 |
Purified His-tagged VDR protein(Fragment) was used to produced this monoclonal antibody.
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克隆号 |
517CT23.5.1
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亚型 |
IgA
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通用名 |
NR1I1
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基因ID |
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UniProt ID |
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功能 |
Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
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总结 |
This gene encodes the nuclear hormone receptor for vitaminD3. This receptor also functions as a receptor for the secondarybile acid lithocholic acid. The receptor belongs to the family oftrans-acting transcriptional regulatory factors and shows sequencesimilarity to the steroid and thyroid hormone receptors. Downstreamtargets of this nuclear hormone receptor are principally involvedin mineral metabolism though the receptor regulates a variety ofother metabolic pathways, such as those involved in the immuneresponse and cancer. Mutations in this gene are associated withtype II vitamin D-resistant rickets. A single nucleotidepolymorphism in the initiation codon results in an alternatetranslation start site three codons downstream. Alternativesplicing results in multiple transcript variants encoding the sameprotein.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:2000
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图像 |
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说明书 |
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数量 |
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