全部产品分类
品牌 |
Leading Biology | 货号 |
AMM02437G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MVP Antibody (N-term) (Ascites).
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分子量 |
99327 Da
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus, nuclear pore complex. Note=5% found in the nuclear pore complex. Translocates from the nucleus to the cytoplasm upon EGF treatment
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宿主 |
Mouse
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种属反应性 |
Human
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免疫原 |
12-39 aa
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靶点 |
This MVP antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 12-39 amino acids from the N-terminal region of human MVP.
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克隆号 |
599CT2.4.1
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亚型 |
IgG1
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通用名 |
LRP
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基因ID |
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UniProt ID |
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功能 |
Required for normal vault structure. Vaults are multi- subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo- cytoplasmic transport. Down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases.
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总结 |
This gene encodes the major vault protein which is a lungresistance-related protein. Vaults are multi-subunit structuresthat may be involved in nucleo-cytoplasmic transport. This proteinmediates drug resistance, perhaps via a transport process. It iswidely distributed in normal tissues, and overexpressed inmultidrug-resistant cancer cells. The protein overexpression is apotentially useful marker of clinical drug resistance. This geneproduces two transcripts by using two alternative exon 2 sequences;however, the open reading frames are the same in both transcripts.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:100~1600
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图像 |
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说明书 |
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数量 |
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