全部产品分类
品牌 |
Leading Biology | 货号 |
AMM02379G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality SNX6 Antibody (Ascites).
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分子量 |
46649 Da
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细胞定位 |
Antigen Cellular Localization:
Early endosome. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasmic vesicle. Cytoplasm. Nucleus Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes (PubMed:19935774). Only a minor proportion is seen in the nucleus.
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宿主 |
Mouse
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种属反应性 |
Human
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靶点 |
This SNX6 monoclonal antibody is generated from mouse immunized with SNX6 recombinant protein.
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克隆号 |
335CT6.4.6
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亚型 |
IgG1
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基因ID |
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UniProt ID |
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功能 |
Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable).
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总结 |
This gene encodes a member of the sorting nexin family.Members of this family contain a phox (PX) domain, which is aphosphoinositide binding domain, and are involved in intracellulartrafficking. This protein associates with the long isoform of theleptin receptor, the transforming growth factor-beta family ofreceptor serine-threonine kinases, and with receptor tyrosinekinases for platelet-derived growth factor, insulin, and epidermalgrowth factor. This protein may form oligomeric complexes withfamily member proteins through interactions of both the PX domainand the coiled coil regions of the molecules. Translocation of thisprotein from the cytoplasm to the nucleus occurs after binding toproviral integration site 1 protein. This gene results in twotranscripts encoding two distinct isoforms.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:1000~16000
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图像 |
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说明书 |
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数量 |
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