全部产品分类
品牌 |
Leading Biology | 货号 |
AMM02357G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CAMKK2 Antibody.
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分子量 |
64746 Da
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细胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Cell projection. Note=Predominantly nuclear in unstimulated cells (By similarity). Found in the cytoplasm and neurites after forskolin induction.
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宿主 |
Mouse
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种属反应性 |
Human, Mouse
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靶点 |
This CAMKK2 monoclonal antibody is generated from mouse immunized with CAMKK2 recombinant protein.
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克隆号 |
239CT7.5.3
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亚型 |
IgM,k
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通用名 |
CAMKKB, KIAA0787
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基因ID |
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UniProt ID |
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功能 |
Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin- binding domain are inactive. Efficiently phosphorylates 5'-AMP- activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
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总结 |
The product of this gene belongs to the Serine/Threonineprotein kinase family, and to the Ca(2+)/calmodulin-dependentprotein kinase subfamily. This protein plays a role in thecalcium/calmodulin-dependent (CaM) kinase cascade byphosphorylating the downstream kinases CaMK1 and CaMK4. Seventranscript variants encoding six distinct isoforms have beenidentified for this gene. Additional splice variants have beendescribed but their full-length nature has not been determined. Theidentified isoforms exhibit a distinct ability to undergoautophosphorylation and to phosphorylate the downstream kinases.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, E
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稀释方法 |
WB~~1:100~250
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图像 |
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说明书 |
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数量 |
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