全部产品分类
品牌 |
Leading Biology | 货号 |
AMP00004G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Functional CD40 (mouse) Antibody, mAb.
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分子量 |
32093 Da
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细胞定位 |
Antigen Cellular Localization:
Isoform I: Cell membrane; Single-pass type I membrane protein Isoform IV: Cell membrane; Single-pass type I membrane protein Isoform II: Secreted.
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宿主 |
Purified From Concentrated Hybridoma Tissue Culture Supernatant.
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种属反应性 |
Mouse
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靶点 |
Recognizes mouse CD40.
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克隆号 |
FGK45
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亚型 |
Rat IgG2a
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通用名 |
Tnfrsf5
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基因ID |
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UniProt ID |
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功能 |
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
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总结 |
CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary.
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形式 |
Liquid. In PBS containing 0.02% sodium azide.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
FC
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说明书 |
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数量 |
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