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> 抗原抗体、ELISA、WB > 一抗 > Monoclonal Antibodies > CD45RO (T-Cell Marker) Antibody - With BSA and Azide品牌 |
Leading Biology | 货号 |
AMM00194G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CD45RO (T-Cell Marker) Antibody - With BSA and Azide.
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分子量 |
180-185kDa
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细胞定位 |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein Membrane raft. Note=Colocalized with DPP4 in membrane rafts
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宿主 |
Mouse
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种属反应性 |
Human
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靶点 |
Cultured human T-cells from an IL-2-dependent T-cell line (CA1)
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克隆号 |
UCHL-1
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亚型 |
IgG2a, kappa
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通用名 |
CD45
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基因ID |
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UniProt ID |
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功能 |
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
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总结 |
Recognizes a 180-185kDa protein, identified as isoform of leukocyte common antigen (CD45RO) (4th Leucocyte Typing Workshop: Code No. N31). The epitope recognized by this antibody is sensitive to neuraminidase digestion. This antibody reacts with mature activated T-cells, most thymocytes, and a sub-population of resting T-cells within both CD4 and CD8 subsets. It shows no reactivity with normal B or natural killer cells, but reacts with granulocytes and monocytes. Reportedly, it is useful to identify T-cell lymphomas and leukemias. It rarely stains NK cells or B-cell lymphomas.
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形式 |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC, IF, FC, IP, E
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图像 |
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说明书 |
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数量 |
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