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> 抗原抗体、ELISA、WB > 一抗 > Monoclonal Antibodies > Involucrin (Squamous Cell Terminal Differentiation Marker) Antibody - With BSA and Azide品牌 |
Leading Biology | 货号 |
AMM00187G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Involucrin (Squamous Cell Terminal Differentiation Marker) Antibody - With BSA and Azide.
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分子量 |
66-170kDa
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细胞定位 |
Antigen Cellular Localization:
Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope
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宿主 |
Mouse
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种属反应性 |
Human
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靶点 |
Purified involucrin from human keratinocytes
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克隆号 |
SY5
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亚型 |
IgG1, kappa
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基因ID |
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UniProt ID |
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功能 |
Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
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总结 |
It recognizes a protein of 66kDa-170kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this MAb reacts with a 120kDa protein. It stains the involucrin in a variety of sizes: 170kDa in MCF-7 cells, a doublet of ~115kDa and 150kDa in gorilla and owl monkey, 66kDa in dog, and a doublet of 105kDa in pig. Its epitope maps between codon 421-568 of human involucrin. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.
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形式 |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
WB, IHC, FC, IP, E
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说明书 |
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数量 |
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