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> 抗原抗体、ELISA、WB > 一抗 > Monoclonal Antibodies > Melanoma Marker (MART-1 + gp100 + Tyrosinase) Antibody - With BSA and Azide品牌 |
Leading Biology | 货号 |
AMM00159G |
产品分类 |
Monoclonal Antibodies | 研究领域 |
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产品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Melanoma Marker (MART-1 + gp100 + Tyrosinase) Antibody - With BSA and Azide.
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分子量 |
20-22kDa (doublet) (MART); 70-80kDa (Tyrosinase); 90-100kDa (gp100)
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细胞定位 |
Antigen Cellular Localization:
Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post- Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation
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宿主 |
Mouse
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种属反应性 |
Human
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靶点 |
Recombinant hMART-1 protein (M2-7C10; M2-9E3); Recombinant tyrosinase protein (T311); Extract of pigmented melanoma metastases from lymph nodes (HMB45)
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克隆号 |
M2-7C10 + M2-9E3 + T311 + HMB45
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亚型 |
IgG2b (M2-7C10 & M2-9E3) + IgG2a (T311) + IgG1 (HMB45)
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通用名 |
MART1
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基因ID |
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UniProt ID |
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功能 |
Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
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总结 |
This antibody cocktail recognizes three melanoma-specific proteins, which include MART-1, Tyrosinase and gp100. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Function of gp100 is not known but it is reported to be a useful marker for melanocytes and melanomas. This cocktail of three markers is designed for extremely sensitive labeling of formalin-fixed, paraffin-embedded melanomas and other tumors showing melanocytic differentiation.
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形式 |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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储存条件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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应用 |
IHC
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图像 |
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说明书 |
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数量 |
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