全部产品分类
品牌 |
Leading Biology | 货号 |
LM21233 |
产品分类 |
单克隆抗体 | 研究领域 |
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产品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
The product of this gene belongs to the integrin betachain family of proteins. Integrins are integral cell-surfaceproteins composed of an alpha chain and a beta chain. This geneencodes the integrin beta chain beta 2. A given chain may combinewith multiple partners resulting in different integrins. Forexample, beta 2 combines with the alpha L chain to form theintegrin LFA-1, and combines with the alpha M chain to form theintegrin Mac-1. Integrins are known to participate in cell adhesionas well as cell-surface mediated signalling. Defects in this geneare the cause of leukocyte adhesion deficiency type I (LAD1). Twotranscript variants encoding the same protein have been identifiedfor this gene.
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浓度 |
Purified His-tagged ITGB2 protein(Fragment) was used to produced this monoclonal antibody. |
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纯度 |
Mouse |
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试剂准备 |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
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复溶 |
Gjelstrup, L.C., et al. J. Immunol. 185(7):4154-4168(2010)
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Chen, X., et al. Proc. Natl. Acad. Sci. U.S.A. 107(33):14727-14732(2010)
Pliyev, B.K., et al. Biochem. Biophys. Res. Commun. 397(2):277-282(2010)
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储存条件 |
Human
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储存溶液 |
ITGB2; CD18; MFI7; Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150, 95 subunit beta; Complement receptor C3 subunit beta; CD_antigen=CD18; Flags: Precursor
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应用 |
WB~~ 1:1000
IHC-P~~1:25
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产品描述 |
Function
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha- D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.
Cellular_Location
Membrane; Single-pass type I membrane protein
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数量 |
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| 选择 | 品牌 | 货号 | 产品名称 | 规格 | 分类 | 研究领域 | 说明书 | 数量 | 目录价 | |
| 1 | Swant | 2D7 | monoclonal anti-Glutamate antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
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￥5096.00 | 订购 询价 | |
| 2 | Leading Biology | LM21248 | Anti-CD36 Antibody (Rabbit Monoclonal antibody) | 100 ul | 单克隆抗体 | Chondrogenesis Markers |
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￥4950.00 | 订购 询价 | |
| 3 | Swant | 288 | Monoclonal antibody to endothelial cells. | 单克隆抗体 |
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￥3243.00 | 订购 询价 | |||
| 4 | Swant | 3A12 | monoclonal anti-GABA antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
|
￥5096.00 | 订购 询价 | |
| 5 | Swant | 345 | Monoclonal antibody to rat pyramidal cells. | 200 µl | 单克隆抗体 | Miscellaneous antibodies |
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￥3243.00 | 订购 询价 | |
| 6 | Swant | 3D5 | monoclonal anti-GABA antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
|
￥5096.00 | 订购 询价 |
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