全部产品分类
品牌 |
Leading Biology | 货号 |
LM21204 |
产品分类 |
单克隆抗体 | 研究领域 |
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产品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
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形式 |
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
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浓度 |
This TLE4 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 262-290 amino acids from the Central region of human TLE4. |
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纯度 |
Mouse |
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试剂准备 |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
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复溶 |
Liu, Y., et al. PLoS Genet. 5 (11), E1000707 (2009) :
Hancock, D.B., et al. PLoS Genet. 5 (8), E1000623 (2009) :
Stolk, L., et al. Nat. Genet. (2009) In press :
Dayyani, F., et al. Blood 111(8):4338-4347(2008)
Heimbucher, T., et al. Mol. Cell. Biol. 27(1):340-351(2007)
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储存条件 |
Human
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储存溶液 |
Transducin-like enhancer protein 4, Grg-4, Groucho-related protein 4, TLE4, GRG4, KIAA1261
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应用 |
WB~~1:100~250
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产品描述 |
Function
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).
Cellular_Location
Nucleus.
Tissue_Location
In all tissues examined, mostly in brain, and muscle
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数量 |
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