品牌 |
Leading Biology | 货号 |
LM21185 |
产品分类 |
单克隆抗体 | 研究领域 |
|
产品概述 |
Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
|
||
形式 |
The Wiskott-Aldrich syndrome (WAS) is an X-chromosome-linked recessive disease characterized by eczema, thrombocytopenia, and immunodeficiency (1). WAS is an immunodeficiency disorder with the most severe pathology in the T lymphocytes and platelets. The disease arises from mutations in the gene encoding the WAS protein (WASP). T lymphocytes of affected males with WAS exhibit a severe disturbance of the actin cytoskeleton, suggesting that the WASP could regulate its organization. Data suggest that the WASP might function as a signal transduction adaptor downstream of Cdc42, and in affected males, the cytoskeletal abnormalities may result from a defect in Cdc42 signaling (2). WASP is a key regulator of the Arp2/3 complex and the actin cytoskeleton in hematopoietic cells. WASP is capable of forming an auto-inhibited conformation, which can be disrupted by binding of Cdc42 and phosphatidylinositol 4,5-bisphosphate, leading to its activation. Stimulation of the collagen receptor on platelets and crosslinking the B-cell receptor induce tyrosine phosphorylation of WASP (3).
|
||
浓度 |
A synthetic peptide corresponding to residues near the C-terminus of human WASP was used as an immunogen. |
||
纯度 |
Rabbit |
||
试剂准备 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
|
||
复溶 |
1. Smith FJ, et al. Biochem Biophys Res Commun. 297(4):818-27, 2002.<br>2. Adley BP, et al. Anal Qnt Cytol Histol 28(4):228-36, 2006<br>3. Coons SW, et al. Endocr Pathol 16(3):201-10, 2005<br>
|
||
储存条件 |
Human
|
||
储存溶液 |
Wiskott-Aldrich syndrome protein, WASp, WAS, IMD2
|
||
应用 |
WB~~1:10000~50000
IHC~~1:100~250
|
||
产品描述 |
Function
Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria.
Cellular_Location
Cytoplasm, cytoskeleton.
Tissue_Location
Expressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen
|
||
数量 |
|
选择 | 品牌 | 货号 | 产品名称 | 规格 | 分类 | 研究领域 | 说明书 | 数量 | 目录价 | |
1 | Swant | 2D7 | monoclonal anti-Glutamate antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
|
¥5096.00 | 订购 询价 | |
2 | Leading Biology | LM21248 | Anti-CD36 Antibody (Rabbit Monoclonal antibody) | 100 ul | 单克隆抗体 | Chondrogenesis Markers |
|
¥4950.00 | 订购 询价 | |
3 | Swant | 288 | Monoclonal antibody to endothelial cells. | 单克隆抗体 |
|
¥3243.00 | 订购 询价 | |||
4 | Swant | 3A12 | monoclonal anti-GABA antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
|
¥5096.00 | 订购 询价 | |
5 | Swant | 345 | Monoclonal antibody to rat pyramidal cells. | 200 µl | 单克隆抗体 | Miscellaneous antibodies |
|
¥3243.00 | 订购 询价 | |
6 | Swant | 3D5 | monoclonal anti-GABA antibody | 200 µl | 单克隆抗体 | Antibodies against neurotransmitters |
|
¥5096.00 | 订购 询价 |
微信扫描二维码,随时随地与小诺亲密接触,精彩活动,劲爆优惠,触手可得!