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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > 单克隆抗体 > SVIL Antibody (monoclonal) (M03)

SVIL Antibody (monoclonal) (M03)

LM21073
货号 货期 规格 / 价格 询价

SVIL Antibody (monoclonal) (M03)

品牌

Leading Biology

货号

LM21073

产品分类

单克隆抗体

研究领域

产品概述

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.

形式

This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Two transcript variants encoding different isoforms of supervillin have been described.

浓度

SVIL (NP_003165, 1679 a.a. ~ 1786 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

纯度

mouse

试剂准备

Clear, colorless solution in phosphate buffered saline, pH 7.2.

复溶

Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.The membrane-associated protein, supervillin, accelerates F-actin-dependent rapid integrin recycling and cell motility. Fang Z, et al. Traffic, 2010 Jun. PMID 20331534.How to arm a supervillin: designing F-actin binding activity into supervillin headpiece. Brown JW, et al. J Mol Biol, 2009 Oct 30. PMID 19683541.Supervillin reorganizes the actin cytoskeleton and increases invadopodial efficiency. Crowley JL, et al. Mol Biol Cell, 2009 Feb. PMID 19109420.Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. Horikawa Y, et al. Clin Cancer Res, 2008 Dec 1. PMID 19047128.

储存条件

Human

储存溶液

Supervillin, Archvillin, p205/p250, SVIL

应用

WB~~1:500~1000

数量

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